May 01 2021 SLCO1B1 solute carrier organic anion transporter family member 1B1 is an important transmembrane hepatic uptake transporter. Genetic variants in the SLCO1B1 gene have been associated with altered protein folding resulting in protein degradation and decreased transporter activity. Next generation sequencing NGS of pharmacogenes is being applied
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Characterizations of the structural configurations of human gut microbial communities are beginning to reveal differences between healthy individuals and those with various diseases 1–6 .Experiments involving transplantation of intact uncultured microbiota from healthy humans to humans with colitis induced by Clostridium difficile or patients with metabolic syndrome
Mar 25 2021 The cytospin slides were stored in 70 ethanol under 4 C until IHC or RNA ISH. Saliva cell blocks saliva samples were diluted in 10 volumes of 4 paraformaldehyde in 1 PBS. Cells were allowed to fix for 24 h at room temperature. After 5 min of centrifugation at 1 000 g cell pellets were transferred to 70 ethanol.
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Nov 02 2021 He et al. provide a detailed characterization of dynamic temporal changes in cell signaling and metabolism during macrophage polarization by using quantitative time course proteomics and phosphoproteomics and identify pharmacologic inhibitors of M2 type macrophage polarization. These data uncover a critical role of MEK/ERK signaling for PPARγ/retinoic acid
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Nov 07 2012 Anatomy and immunology of the skin. The outermost section of the skin is the epidermis a stratified squamous epithelium that is usually about 0.1 mm thick but can be from 0.8 to 1.4 mm on the palms and soles Figure 61 1A .The stratum malpighii layer comprises the primary component of the epidermis and its dividing and growing keratinocytes serve both a
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Nov 05 2021 EMBL is an intergovernmental organisation headquartered in Heidelberg and was founded in 1974 with the mission of promoting molecular biology research in Europe training young scientists and developing new technologies. EMBL currently employs more than 1800 people in Barcelona Grenoble Hamburg Heidelberg EMBL EBI Hinxton near Cambridge
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