Rats with bilateral excitotoxic lesions of the basolateral amygdala readily acquired the IV self administration of cocaine under a continuous reinforcement schedule initially administering more infusions and maintaining a slightly elevated level of self administration than controls.
Oct 27 2020 Intravenous THC self administration lever extinction and reinstatement. During self administration adolescent rats PD 32–51 were food restricted to 13–18 g of rat chow per day. Rats were trained to lever press for THC in standard operant conditioning chambers Med Associates St Albans VT during daily 2 h sessions.
Shaham Y. and Stewart J. 1994 . Exposure to mild stress enhances the reinforcing efficacy of intravenous heroin self administration in rats. Psychopharmacology 114 523–527. doi 10.1007/bf. PubMed Abstract CrossRef Full Text Google Scholar
Intravenous self administration of MDMA is inconsistent. Mephedrone was a more effective reinforcer than MDMA or methylone. Within training groups all three drugs were of identical efficacy and potency. Mephedrone trained rats self administered more than the other groups.
In the present study the self administration and conditioned place preference paradigms were used to determine whether the failure of some rats to acquire intravenous cocaine self administration
Jan 17 2015 The intravenous self administration IVSA of 3 4 methylenedioxymethamphetamine MDMA is not robust in rat models De La Garza et al. 2007 Feduccia et al. 2010 is often marked by inter subject inconsistency Dalley et al. 2007 and in some paradigms approximately 40–50 of the sample fails to meet specific acquisition criteria
Rationale and objective Intravenous infusions of nicotine appear to exert little primary reinforcing effects in adult rats but instead maintain self administration behavior at least in part by increasing the intrinsic reinforcing effects of drug paired sensory stimuli.
IV ethanol self administration has been reliably demonstrated in mouse and human experimental models however models of IV self administration have been historically problematic in the rat. An operant multiple schedule study design was used to elucidate the role of each component of a compound IV ethanol plus oral sucrose reinforcer.
vascular route of administration in the present study we test the hypothesis that intravenous infusion of MSCs from marrow reduces functional deficits after stroke in rats. Materials and Methods Animal Middle Cerebral Artery Occlusion Model Adult male Wistar rats n532 weighing 270 to 300 g were used in our experiments.
With the exception of the 0.056 0.1 0.3 and 1.0 mg/kg/inj. training dose regimens intravenous iv self administration of morphine was acquired at the dose of 0.56 mg/kg/inj. and subsequently maintained by rats. In contrast to morphine self administration rats rapidly acquired cocaine self administration behavior at either the 0.3 or 0.56
Environmental enrichment decreases intravenous self administration of amphetamine in female and male rats. Publication Type Journal Article Google Scholar Department of Psychology 106 B Kastle Hall University of Kentucky Lexington KY 40506 0044 Tel 859 257 9640 Fax 859 323 1979
Jan 30 2013 Groups of male Wistar and Sprague‐Dawley rats were prepared with intravenous catheters and trained to self‐administer 4‐MMC in 1‐hour sessions. Per‐infusion doses of 0.5 and 1.0 mg/kg were consistently self‐administered resulting in greater than 80 discrimination for the drug‐paired lever and mean intakes of about 2–3 mg/kg/hour.
The intravenous self administration IVSA of 3 4 methylenedioxymethamphetamine MDMA is inconsistent in rats with up to half of subjects failing to acquire reliable drug intake. It is unknown if this changes under long access conditions 6 h sessions under which the IVSA of cocaine and methamphetamine escalates.
Menthol facilitates the intravenous self administration of nicotine in rats Tengfei eWang Bin eWang Hao eChen Affiliations Tengfei eWang University of Tennessee Health Science Center Bin eWang Shaanxi University of Chinese Medicine Hao eChen University of Tennessee Health Science Center
Results demonstrate that most rats strongly prefer palatable food pellets over intravenous methamphetamine confirming previous studies using discrete choice procedures with intravenous cocaine. Results also demonstrate that escalation of drug self administration a popular model of compulsive drug use is not associated with a cardinal feature
Most surprising is that the infusion dose 1 2 mg/kg that reliably maintains IV alcohol self administration in rats results in total alcohol intakes of only 20 25 mg/kg/hour which are unlikely to have significant pharmacological effects.
Sep 01 2013 Groups of male Wistar and Sprague‐Dawley rats were prepared with intravenous catheters and trained to self‐administer 4‐MMC in 1‐hour sessions. Per‐infusion doses of 0.5 and 1.0 mg/kg were consistently self‐administered resulting in greater than 80 discrimination for the drug‐paired lever and mean intakes of about 2–3 mg/kg/hour.
Sep 01 2002 Intravenous self administration in trained rats Under anaesthesia with chloral hydrate 400 mg/kg i.p. rats were surgically implanted with a chronic catheter. Briefly under sterile conditions a silastic catheter was inserted into the right jugular vein tunnelled under the skin and exited in the midscapular region and was anchored to the
Effects of Nicotine in Rats Intravenous Self Administration Drug Discrimination and Locomotor Cross Sensitization Thomas E Wooters 1 Nichole M Neugebauer 1 Craig R Rush 1 2 3 and Michael T
Nov 01 2000 The role for corticotropin releasing hormone CRH receptors in the maintenance of intravenous cocaine self administration in rats was investigated using the centrally active small molecule CRH1
Request PDF On Sep 1 2008 Joanne Price and others published Implementation of the 3R s in the rat intravenous drug self administration model
Jul 08 1985 Intravenous self administration of heroin was studied in experimentally naive rats as compared to this behavior in animals rendered tolerant to heroin by multiple injections. The tolerant rats also exhibited mild signs of spontaneous and naloxone precipitated heroin withdrawal. Self administration behavior developed earlier in the tolerant rats.
Intravenous self administration of delta 9 THC in adolescent rats produces long lasting alterations in behavior and receptor protein expression Stringfield SJ Torregrossa MM Some information on this page may be suppressed.
The total quantity of morphine taken by rats during 22 day morphine self administration was 102.74 ± 4.77 mg/rat with a daily number of infusions during the last 3 sessions of maintenance of morphine self administration in two trained groups ranging between 11.7 ±
Oct 11 2006 Cognitive sequelae of intravenous amphetamine self administration in rats evidence for selective effects on attentional performance. Neuropsychopharmacology 30 525–537. CAS Article Google Scholar
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